Selection for immune evasion in SARS-CoV-2 revealed by high-resolution epitope mapping and sequence analysis.

ABSTRACT: Here, we exploit a deep serological profiling strategy coupled with an integrated, computational framework for the analysis of SARS-CoV-2 humoral immune responses. Applying a high-density peptide array (HDPA) spanning the entire proteomes of SARS-CoV-2 and endemic human coronaviruses allowed identification of B cell epitopes and relate them to their evolutionary and structural properties. We identify hotspots of pre-existing immunity and identify cross-reactive epitopes that contribute to increasing the overall humoral immune response to SARS-CoV-2. Using a public dataset of over 38,000 viral genomes from the early phase of the pandemic, capturing both inter- and within-host genetic viral diversity, we determined the evolutionary profile of epitopes and the differences across proteins, wav

SUBMITTER: N'Guessan A 

PROVIDER: S-EPMC10433132 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature