Association Between Fluoroquinolone Use and Hospitalization With Aortic Aneurysm or Aortic Dissection.

ABSTRACT:

Importance

Fluoroquinolone use has been associated with increased hospitalization with aortic aneurysm or dissection in noninterventional studies, but the reason for this observed association is unclear.

Objective

To determine the association between fluoroquinolone use and aortic aneurysm or dissection using multiple study designs and multiple databases to increase the robustness of findings.

Design, setting, and participants

Cohort and case-crossover studies were conducted separately in 2 databases of UK primary care records. Clinical Practice Research Datalink Aurum and GOLD primary care records were linked to hospital admissions data. Adults with a systemic fluoroquinolone or cephalosporin prescription between April 1997 and December 2019 were included in the coho

SUBMITTER: Brown JP 

PROVIDER: S-EPMC10433140 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature