Evaluation of bone mineral density and bone turnover in children on anticoagulation.

ABSTRACT:

Background

Childhood and adolescence are critical periods of bone mineral acquisition. Children on anticoagulation (AC) might have an increased risk for reduced bone mineral density (BMD). Risk factors for impaired bone accumulation include chronic diseases, immobility, and medication. Vitamin K (VK) deficiency reflected by undercarboxylated osteocalcin levels (ucOC) has been identified as a predictor of osteoporosis and fractures. Data on bone health in children under AC are sparse.

Aims

To evaluate BMD in children on AC and characterize the risk factors of low BMD, including VK and Vitamin D (VD) status.

Methods

Single-center cross-sectional study of clinical, biochemical, and densitometric parameters. Assessment of VK surrogate parameters included ucOC and matrix g

SUBMITTER: Thom K 

PROVIDER: S-EPMC10433196 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature