Rheumatoid arthritis and hypothyroidism: a bidirectional Mendelian randomization study.

ABSTRACT:

Object

Though significant correlations between rheumatoid arthritis (RA) and hypothyroidism have been found in earlier observational studies, their underlying causal relationship is still unknown. Mendelian randomization (MR) was used in the current study to assess the bidirectional causation between RA and hypothyroidism.

Method

We gathered summary data from genome-wide association studies (GWASs) of RA and hypothyroidism in people of European descent. Then, using data from the FinnGen consortium, we replicated our findings. Three approaches were employed to assess the causal link between RA and hypothyroidism: MR-Egger, weighted median (WM), and inverse variance weighted (IVW). The pleiotropy and heterogeneity were examined using a variety of techniques, including the MR-E

SUBMITTER: Duan L 

PROVIDER: S-EPMC10433205 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature