Prognostic value of soluble ST2 in AL and TTR cardiac amyloidosis: a multicenter study.

ABSTRACT:

Background

Both light-chain (AL) amyloidosis and transthyretin (ATTR) amyloidosis are types of cardiac amyloidosis (CA) that require accurate prognostic stratification to plan therapeutic strategies and follow-ups. Cardiac biomarkers, e.g., N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (Hs-cTnT), remain the cornerstone of the prognostic assessment. An increased level of soluble suppression of tumorigenesis-2 (sST2) is predictive of adverse events [all-cause death and heart failure (HF) hospitalizations] in patients with HF. This study aimed to evaluate the prognostic value of circulating sST2 levels in AL-CA and ATTR-CA.

Methods

We carried out a multicenter study including 133 patients with AL-CA and 152 patients with ATTR-CA.

SUBMITTER: Nicol M 

PROVIDER: S-EPMC10433216 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature