Leukotriene signaling as molecular correlate for cognitive heterogeneity in aging: an exploratory study.

ABSTRACT:

Introduction

Aging is in general associated with a decline in cognitive functions. Looking more closely, there is a huge heterogeneity in the extent of cognitive (dys-)abilities in the aged population. It ranges from the population of resistant, resilient, cognitively unimpaired individuals to patients with severe forms of dementias. Besides the known genetic, environmental and life style factors that shape the cognitive (dys-)abilities in aging, the underlying molecular mechanisms and signals related to cognitive heterogeneity are completely unknown. One putative mechanism underlying cognitive heterogeneity might be neuroinflammation, exerted through microglia, the brain's innate immune cells, as neuroinflammation is central to brain aging and neurodegenerative diseases. Recently,

SUBMITTER: Mrowetz H 

PROVIDER: S-EPMC10433382 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature