LncRNA and circRNA expression profiles in the hippocampus of Aβ_25‑35‑induced AD mice treated with Tripterygium glycoside.

ABSTRACT: Tripterygium glycosides (TG) have been reported to ameliorate Alzheimer's disease (AD), although the mechanism involved remains to be determined. In the present study, the lncRNA and circRNA expression profiles of an AD mouse model treated with TG were assessed using microarrays. lncRNAs, mRNAs, and circRNAs in the hippocampi of 3 AD+normal saline (NS) mice and 3 AD+TG mice were detected using microarrays. The most differentially expressed lncRNAs, mRNAs, and circRNAs were screened between the AD+NS and AD+TG groups. The differentially expressed lncRNAs and circRNAs were analyzed using GO enrichment and KEGG analyses. Co-expression analysis of lncRNAs, circRNAs, and mRNAs was performed by calculating the correlation coefficients. Protein-protein interaction (PPI) network analysis was perfo

SUBMITTER: Tang L 

PROVIDER: S-EPMC10433443 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature