Nanomechanoelectrical approach to highly sensitive and specific label-free DNA detection.

ABSTRACT: Electronic detection of DNA oligomers offers the promise of rapid, miniaturized DNA analysis across various biotechnological applications. However, known all-electrical methods, which solely rely on measuring electrical signals in transducers during probe-target DNA hybridization, are prone to nonspecific electrostatic and electrochemical interactions, subsequently limiting their specificity and detection limit. Here, we demonstrate a nanomechanoelectrical approach that delivers ultra-robust specificity and a 100-fold improvement in detection limit. We drive nanostructural DNA strands tethered to a graphene transistor to oscillate in an alternating electric field and show that the transistor-current spectra are characteristic and indicative of DNA hybridization. We find that the inherent d

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10433451 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature