Four-parameter analysis in modified Rotarod test for detecting minor motor deficits in mice.

ABSTRACT:

Background

The Rotarod test with commercial apparatus is widely used to assess locomotor performance, balance and motor learning as well as the deficits resulting from diverse neurological disorders in laboratory rodents due to its simplicity and objectivity. Traditionally, the test ends when rodents drop from the accelerating, turning rod, and the only parameter used commonly is "latency to fall". The values of individual animals can often vary greatly.

Results

In the present study, we established a procedure for mice with 4 consecutive days of training with 4 trials per day and modified the testing procedure by placing the mice back on the rod repeatedly after each fall until the trial ends (5 min). Data from the fourth training day as baseline results showed that the seco

SUBMITTER: Shan HM 

PROVIDER: S-EPMC10433596 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature