Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges.

ABSTRACT: Skin wounds are characterized by injury to the skin due to trauma, tearing, cuts, or contusions. As such injuries are common to all human groups, they may at times represent a serious socioeconomic burden. Currently, increasing numbers of studies have focused on the role of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) in skin wound repair. As a cell-free therapy, MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell therapy. Treatment based on MSC-derived EVs can significantly promote the repair of damaged substructures, including the regeneration of vessels, nerves, and hair follicles. In addition, MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and

SUBMITTER: Ding JY 

PROVIDER: S-EPMC10433599 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature