High-resolution strain-level microbiome composition analysis from short reads.

ABSTRACT:

Background

Bacterial strains under the same species can exhibit different biological properties, making strain-level composition analysis an important step in understanding the dynamics of microbial communities. Metagenomic sequencing has become the major means for probing the microbial composition in host-associated or environmental samples. Although there are a plethora of composition analysis tools, they are not optimized to address the challenges in strain-level analysis: highly similar strain genomes and the presence of multiple strains under one species in a sample. Thus, this work aims to provide a high-resolution and more accurate strain-level analysis tool for short reads.

Results

In this work, we present a new strain-level composition analysis tool named StrainScan

SUBMITTER: Liao H 

PROVIDER: S-EPMC10433603 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature