Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD.

ABSTRACT:

Background

Alveolar macrophages (AMs) and AM-produced matrix metalloprotease (MMP)-12 are known to play critical roles in the pathogenesis of chronic obstructive pulmonary disease (COPD). The apoptosis inhibitor of the macrophages (AIM)/CD5 molecule-like (CD5L) is a multifunctional protein secreted by the macrophages that mainly exists in the blood in a combined form with the immunoglobulin (Ig)M pentamer. Although AIM has both facilitative and suppressive roles in various diseases, its role in COPD remains unclear.

Methods

We investigated the role of AIM in COPD pathogenesis using porcine pancreas elastase (PPE)-induced and cigarette smoke-induced emphysema mouse models and an in vitro model using AMs. We also analyzed the differences in the blood AIM/IgM ratio among nonsmo

SUBMITTER: Takimoto-Sato M 

PROVIDER: S-EPMC10433671 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature