Preparation and PET/CT imaging of implant directed ⁶⁸Ga-labeled magnetic nanoporous silica nanoparticles.

ABSTRACT:

Background

Implant infections caused by biofilm forming bacteria are a major threat in orthopedic surgery. Delivering antibiotics directly to an implant affected by a bacterial biofilm via superparamagnetic nanoporous silica nanoparticles could present a promising approach. Nevertheless, short blood circulation half-life because of rapid interactions of nanoparticles with the host's immune system hinder them from being clinically used. The aim of this study was to determine the temporal in vivo resolution of magnetic nanoporous silica nanoparticle (MNPSNP) distribution and the effect of PEGylation and clodronate application using PET/CT imaging and gamma counting in an implant mouse model.

Methods

PEGylated and non-PEGylated MNPSNPs were radiolabeled with gallium-68 (⁶⁸

SUBMITTER: Polyak A 

PROVIDER: S-EPMC10433681 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature