Electroactive nanoinjection platform for intracellular delivery and gene silencing.

ABSTRACT:

Background

Nanoinjection-the process of intracellular delivery using vertically configured nanostructures-is a physical route that efficiently negotiates the plasma membrane, with minimal perturbation and toxicity to the cells. Nanoinjection, as a physical membrane-disruption-mediated approach, overcomes challenges associated with conventional carrier-mediated approaches such as safety issues (with viral carriers), genotoxicity, limited packaging capacity, low levels of endosomal escape, and poor versatility for cell and cargo types. Yet, despite the implementation of nanoinjection tools and their assisted analogues in diverse cellular manipulations, there are still substantial challenges in harnessing these platforms to gain access into cell interiors with much greater precision w

SUBMITTER: Shokouhi AR 

PROVIDER: S-EPMC10433684 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature