MICU1 and MICU2 potentiation of Ca²⁺ uptake by the mitochondrial Ca²⁺ uniporter of Trypanosoma cruzi and its inhibition by Mg².

ABSTRACT: The mitochondrial Ca²⁺ uptake, which is important to regulate bioenergetics, cell death and cytoplasmic Ca²⁺ signaling, is mediated via the calcium uniporter complex (MCUC). In animal cells the MCUC is regulated by the mitochondrial calcium uptake 1 and 2 dimer (MICU1/MICU2), which has been proposed to act as gatekeeper preventing mitochondrial Ca²⁺ overload at low cytosolic Ca²⁺ levels. In contrast to animal cells, knockout of either MICU1 or MICU2 in Trypanosoma cruzi, the etiologic agent of Chagas disease, did not allow Ca²⁺ uptake at low extramitochondrial Ca²⁺ concentrations ([Ca²⁺]_ext) and it was though that in the absence of one MICU the other would replace its role. However, previous attempts to

SUBMITTER: Bertolini MS 

PROVIDER: S-EPMC10433726 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature