Suppression of neutrophils by sodium exacerbates oxidative stress and arthritis.

ABSTRACT:

Introduction

Typical Western diet, rich in salt, contributes to autoimmune disease development. However, conflicting reports exist about the effect of salt on neutrophil effector functions, also in the context of arthritis.

Methods

We investigated the effect of sodium chloride (NaCl) on neutrophil viability and functions in vitro, and in vivo employing the murine K/BxN-serum transfer arthritis (STA) model.

Results and discussion

The effects of NaCl and external reactive oxygen species (H₂O₂) were further examined on osteoclasts in vitro. Hypertonic sodium-rich media caused primary/secondary cell necrosis, altered the nuclear morphology, inhibited phagocytosis, degranulation, myeloperoxidase (MPO) peroxidation activity and neu

SUBMITTER: Zlatar L 

PROVIDER: S-EPMC10433750 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature