A pathway model of glucose-stimulated insulin secretion in the pancreatic β-cell.

ABSTRACT: The pancreas plays a critical role in maintaining glucose homeostasis through the secretion of hormones from the islets of Langerhans. Glucose-stimulated insulin secretion (GSIS) by the pancreatic β-cell is the main mechanism for reducing elevated plasma glucose. Here we present a systematic modeling workflow for the development of kinetic pathway models using the Systems Biology Markup Language (SBML). Steps include retrieval of information from databases, curation of experimental and clinical data for model calibration and validation, integration of heterogeneous data including absolute and relative measurements, unit normalization, data normalization, and model annotation. An important factor was the reproducibility and exchangeability of the model, which allowed the use of vario

SUBMITTER: Deepa Maheshvare M 

PROVIDER: S-EPMC10433753 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature