Identification of Potential Novel B-Cell Epitopes of Capsid Protein VP2 in Senecavirus A.

ABSTRACT: Senecavirus A (SVA) is a type of nonenveloped single-stranded, positive-sense RNA virus. The VP2 protein is a structural protein that plays an important role in inducing early and late immune responses of the host. However, its antigenic epitopes have not been fully elucidated. Therefore, defining the B epitopes of the VP2 protein is of great importance to revealing its antigenic characterization. In this study, we analyzed B-cell immunodominant epitopes (IDEs) of the VP2 protein from the SVA strain CH/FJ/2017 using the Pepscan approach and a bioinformatics-based computational prediction method. The following four novel IDEs of VP2 were identified: IDE1, ⁴¹TKSDPPSSSTDQPTTT⁵⁶; IDE2, ¹⁴⁵PDGKAKSLQELNEEQW¹⁶⁰; IDE3, ¹⁶¹VEMSDDYRTGKNMPF¹

SUBMITTER: Ru Y 

PROVIDER: S-EPMC10433816 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature