Aneuploidy Formation in the Filamentous Fungus Aspergillus flavus in Response to Azole Stress.

ABSTRACT: Aspergillus flavus is a mycotoxigenic fungus that contaminates many important agricultural crops with aflatoxin B1, the most toxic and carcinogenic natural compound. This fungus is also the second leading cause of human invasive aspergillosis, after Aspergillus fumigatus, a disease that is particularly prevalent in immunocompromised individuals. Azole drugs are considered the most effective compounds in controlling Aspergillus infections both in clinical and agricultural settings. Emergence of azole resistance in Aspergillus spp. is typically associated with point mutations in cyp51 orthologs that encode lanosterol 14α-demethylase, a component of the ergosterol biosynthesis pathway that is also the target of azoles. We hypothesized that alternative molecular mechanisms are also resp

SUBMITTER: Barda O 

PROVIDER: S-EPMC10433848 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature