Neuron-binding antibody responses are associated with Black ethnicity in multiple sclerosis during natalizumab treatment

ABSTRACT: Abstract Multiple sclerosis is an inflammatory degenerative condition of the central nervous system that may result in debilitating disability. Several studies over the past twenty years suggest that multiple sclerosis manifests with a rapid, more disabling disease course among individuals identifying with Black or Latin American ethnicity relative to those of White ethnicity. However, very little is known about immunologic underpinnings that may contribute to this ethnicity-associated discordant clinical severity. Given the importance of B cells to multiple sclerosis pathophysiology, and prior work showing increased antibody levels in the cerebrospinal fluid of Black-identifying, compared to White-identifying multiple sclerosis patients, we conducted a cohort study to determine B cell sub

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PROVIDER: S-EPMC10433937 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature