Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids.

ABSTRACT: Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To advance informed vaccine design, it is critical that we understand the cellular dynamics underlying responses to different antigen formats. Here, we sought to understand how antigen-specific B and T cells were activated and participated in adaptive immune responses within the mucosal site. Using a human tonsil organoid model, we tracked the differentiation and kinetics of the adaptive immune response to influenza vaccine and virus modalities. Each antigen format elicited distinct B and T cell responses, including differences in their magnitude, diversity, phenotype, function, and breadth. These differences culminated in substantial changes in the corresponding antibody response. A major source of a

SUBMITTER: Kastenschmidt JM 

PROVIDER: S-EPMC10433940 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature