Orally Administered Bifidobacterium adolescentis Diminishes Serum Glutamate Concentration in Mice.

ABSTRACT: Several studies have described the contribution of glutamate-transforming microbiota to the development of chronic ailments. For instance, the blood concentration of glutamate is higher in some patients with fibromyalgia, chronic fatigue, and pain. Taking advantage of a naturally occurring strain of Bifidobacterium that is able to transform glutamate in γ-aminobutyric caid (GABA), B. adolescentis IPLA60004, we designed a placebo-controlled intervention to test if the presence of this GABA-producing bifidobacteria in mice was able to impact the concentration of glutamate in the blood in comparison with the administration of other strain of the same species lacking the genes of the glutamate decarboxylase (gad) cluster. Animals were fed every day with 8 log CFU of bacteria in a

SUBMITTER: Royo F 

PROVIDER: S-EPMC10433951 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature