A Streptomyces tendae Specialized Metabolite Inhibits Quorum Sensing in Group A Streptococcus.

ABSTRACT: Quorum sensing (QS) is a means of bacterial communication accomplished by microbe-produced signals and sensory systems. QS systems regulate important population-wide behaviors in bacteria, including secondary metabolite production, swarming motility, and bioluminescence. The human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]) utilizes Rgg-SHP QS systems to regulate biofilm formation, protease production, and activation of cryptic competence pathways. Given their reliance on small-molecule signals, QS systems are attractive targets for small-molecule modulators that would then affect gene expression. In this study, a high-throughput luciferase assay was employed to screen an Actinobacteria-derived secondary metabolite (SM) fraction library to identify small molecule i

SUBMITTER: Nepomuceno VM 

PROVIDER: S-EPMC10434017 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature