Diversity and Standard Nomenclature of Staphylococcus aureus Hyaluronate Lyases HysA and HysB.

ABSTRACT: Bacterial hyaluronate lyases (Hys) are enzymes that degrade hyaluronic acid in their host and are known to contribute to the pathogenesis of several illnesses. The first two identified Hys genes in Staphylococcus aureus were registered as hysA1 and hysA2. However, their annotations have been mistakenly reversed in some registered assembly data, and different abbreviations (hysA and hysB) in some reports complicates comparative analysis of Hys proteins. We investigated the hys loci of S. aureus genome sequences registered in public databases, analyzed the homology, and defined hysA as hys located in the core genome surrounded by a lactose metabolic operon and a ribosomal protein cluster present in almost all strains and hysB as that lo

SUBMITTER: Hisatsune J 

PROVIDER: S-EPMC10434019 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature