Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus.

ABSTRACT: Tigecycline is an important antibacterial drug for treating infection by clinical multidrug-resistant bacteria, and tigecycline-resistant Staphylococcus aureus (TRSA) has been increasingly reported in recent years. Notably, only rpsJ and mepA are associated with the tigecycline resistance of S. aureus. The mepA gene encodes MepA efflux pumps, and the overexpression of mepA has been confirmed to be directly related to tigecycline resistance. Although the mutations of MepA widely occur, the associations between TRSA and mutations of MepA are still unclear. In this study, we explored mutations in the mepA genes from various sources. Then, tigecycline resistance-associated mutations T29I, E287G, and T29I+E287G in MepA were identified, and their effects were e

SUBMITTER: Huang H 

PROVIDER: S-EPMC10434020 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature