HTLV-1 Proliferation after CD8⁺ Cell Depletion by Monoclonal Anti-CD8 Antibody Administration in Latently HTLV-1-Infected Cynomolgus Macaques.

ABSTRACT: Human T-cell leukemia virus type 1 (HTLV-1) induces chronic asymptomatic latent infection with a substantial proviral load but without significant viral replication in vivo. Cumulative studies have indicated involvement of CD8-positive (CD8⁺) cells, including virus-specific CD8⁺ T cells in the control of HTLV-1 replication. However, whether HTLV-1 expression from latently infected cells in vivo occurs in the absence of CD8⁺ cells remains unclear. Here, we examined the impact of CD8⁺ cell depletion by monoclonal anti-CD8 antibody administration on proviral load in HTLV-1-infected cynomolgus macaques. Five cynomolgus macaques were infected with HTLV-1 by inoculation with HTLV-1-producing cells. Administration of monoclonal anti-CD8 an

SUBMITTER: Nakamura-Hoshi M 

PROVIDER: S-EPMC10434050 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature