Choreography of Lyme Disease Spirochete Adhesins To Promote Vascular Escape.

ABSTRACT: The Lyme disease spirochete Borrelia burgdorferi sensu lato can cause a multitude of clinical manifestations because of its ability to disseminate into any organ system via migration through soft tissue, the lymphatic system, and the circulatory system. The latter is believed to constitute the predominant pathway for dissemination to distal sites from the inoculating tick bite. In spite of its importance, the hematogenous dissemination process remains largely uncharacterized, particularly due to difficulties studying this process in a living host and the lack of an in vitro system that recapitulates animal infection. In the current work, we provide the first information regarding the stage of the vascular transmigration pathway where three important adhesins function during i

SUBMITTER: Tan X 

PROVIDER: S-EPMC10434219 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature