Short-Term Dietary Intervention with Whole Oats Protects from Antibiotic-Induced Dysbiosis.

ABSTRACT: Antibiotic-induced gut microbiome dysbiosis (AID) is known to be influenced by host dietary composition. However, how and when diet modulates gut dysbiosis remains poorly characterized. Thus, here, we utilize a multi-omics approach to characterize how a diet supplemented with oats, a rich source of microbiota-accessible carbohydrates, or dextrose impacts amoxicillin-induced changes to gut microbiome structure and transcriptional activity. We demonstrate that oat administration during amoxicillin challenge provides greater protection from AID than the always oats or recovery oats diet groups. In particular, the group in which oats were provided at the time of antibiotic exposure induced the greatest protection against AID while the other oat diets saw greater effects after amoxicillin chall

SUBMITTER: Costa SK 

PROVIDER: S-EPMC10434222 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature