Functional Characterization of FeoAB in Iron Acquisition and Pathogenicity in Riemerella anatipestifer.

ABSTRACT: The bacterium Riemerella anatipestifer requires iron for growth, but the mechanism of iron uptake is not fully understood. In this study, we disrupted the Feo system and characterized its function in iron import in R. anatipestifer ATCC 11845. Compared to the parent strain, the growth of the ΔfeoA, ΔfeoB, and ΔfeoAB strains was affected under Fe³⁺-limited conditions, since the absence of the feo system led to less intracellular iron than in the parent strain. In parallel, the ΔfeoAB strain was shown to be less sensitive to streptonigrin, an antibiotic that requires free iron to function. The sensitivity of the ΔfeoAB strain to hydrogen peroxide was also observed to be diminished compared with that of the parent strain, which could be rel

SUBMITTER: Huang M 

PROVIDER: S-EPMC10434265 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature