Metabolite Alterations and Interactions with Microbiota in Helicobacter pylori-Associated Gastric Lesions.

ABSTRACT: Metabolites and their interactions with microbiota may be involved in Helicobacter pylori-associated gastric lesion development. This study aimed to explore metabolite alterations upon H. pylori eradication and possible roles of microbiota-metabolite interactions in progression of precancerous lesions. Targeted metabolomics assays and 16S rRNA gene sequencing were conducted to investigate metabolic and microbial alterations of paired gastric biopsy specimens in 58 subjects with successful and 57 subjects with failed anti-H. pylori treatment. Integrative analyses were performed by combining the metabolomics and microbiome profiles from the same intervention participants. A total of 81 metabolites were significantly altered after successful eradication compared to failed treatment, including

SUBMITTER: Peng L 

PROVIDER: S-EPMC10434277 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature