New Multilocus Sequence Typing Scheme for Enterococcus faecium Based on Whole Genome Sequencing Data.

ABSTRACT: The MLST scheme currently used for Enterococcus faecium typing was designed in 2002 and is based on putative gene functions and Enterococcus faecalis gene sequences available at that time. As a result, the original MLST scheme does not correspond to the real genetic relatedness of E. faecium strains and often clusters genetically distant strains to the same sequence types (ST). Nevertheless, typing has a significant impact on the subsequent epidemiological conclusions and introduction of appropriate epidemiological measures, thus it is crucial to use a more accurate MLST scheme. Based on the genome analysis of 1,843 E. faecium isolates, a new scheme, consisting of 8 highly discriminative loci, was created in this study. These strains were divided into 421 STs using the new MLST scheme, as

SUBMITTER: Bezdicek M 

PROVIDER: S-EPMC10434285 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature