Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.

ABSTRACT: Microbes evolve rapidly by modifying their genomes through mutations or through the horizontal acquisition of mobile genetic elements (MGEs) linked with fitness traits such as antimicrobial resistance (AMR), virulence, and metabolic functions. We conducted a multicentric study in India and collected different clinical samples for decoding the genome sequences of bacterial pathogens associated with sepsis, urinary tract infections, and respiratory infections to understand the functional potency associated with AMR and its dynamics. Genomic analysis identified several acquired AMR genes (ARGs) that have a pathogen-specific signature. We observed that bla_CTX-M-15, bla_CMY-42, bla_NDM-5, and aadA(2) were prevalent in Escherichia col

SUBMITTER: Mehrotra T 

PROVIDER: S-EPMC10434301 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature