Silk-protein-based gradient hydrogels with multimode reprogrammable shape changes for biointegrated devices.

ABSTRACT: Biocompatible and morphable hydrogels capable of multimode reprogrammable, and adaptive shape changes are potentially useful for diverse biomedical applications. However, existing morphable systems often rely on complicated structural designs involving cumbersome and energy-intensive fabrication processes. Here, we report a simple electric-field-activated protein network migration strategy to reversibly program silk-protein hydrogels with controllable and reprogrammable complex shape transformations. The application of a low electric field enables the convergence of net negatively charged protein cross-linking networks toward the anode (isoelectric point plane) due to the pH gradient generated in the process, facilitating the formation of a gradient network structure and systems suitable f

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10434304 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature