Bacterial persistence in Legionella pneumophila clinical isolates from patients with recurring legionellosis.

ABSTRACT: Bacterial persisters are a transient subpopulation of non-growing, antibiotic-tolerant cells. There is increasing evidence that bacterial persisters play an important role in treatment failure leading to recurring infections and promoting the development of antibiotic resistance. Current research reveals that recurring legionellosis is often the result of relapse rather than reinfection and suggests that the mechanism of bacterial persistence may play a role. The development of single-cell techniques such as the Timer^bac system allows us to identify potential persister cells and investigate their physiology. Here, we tested the persister forming capacity of 7 pairs of Legionella pneumophila (Lp) clinical isolates, with isolate pairs corresponding to two episodes of

SUBMITTER: Adams-Ward X 

PROVIDER: S-EPMC10434508 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature