Crosstalk between hypoxic cellular micro-environment and the immune system: a potential therapeutic target for infectious diseases.

ABSTRACT: There are overwhelming reports on the promotional effect of hypoxia on the malignant behavior of various forms of cancer cells. This has been proposed and tested exhaustively in the light of cancer immunotherapy. However, there could be more interesting functions of a hypoxic cellular micro-environment than malignancy. There is a highly intricate crosstalk between hypoxia inducible factor (HIF), a transcriptional factor produced during hypoxia, and nuclear factor kappa B (NF-κB) which has been well characterized in various immune cell types. This important crosstalk shares common activating and inhibitory stimuli, regulators, and molecular targets. Impaired hydroxylase activity contributes to the activation of HIFs. Inflammatory ligands activate NF-κB activity, which leads to the expressio

SUBMITTER: Akinsulie OC 

PROVIDER: S-EPMC10434535 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature