Genetic underpinnings of YMRS and MADRS scores variations in a bipolar sample

ABSTRACT:

Introduction

Bipolar disorder (BD) is a chronic hereditary disorder. Trial and error principles and long period of untreated disorder mandate further research. Relatively recent advances in statistical computing and techniques introduced Polygenic risk scores (PRS) as predictors of the genetic susceptibility to diseases. Although they provide an estimate of the risk of developing specific pathologies, they are a genome-wide measure. PRS do not provide specific information on the biological meaning of the variants. The use of subsets of risk variants (limited to one or few related biological pathways) to calculate pathway-PRS (pPRS) may provide an estimate of the functioning of specific molecular cascades.

Objectives

In the present study we calculated pPRS and tested them

SUBMITTER: Calabro M 

PROVIDER: S-EPMC10434663 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature