Metabolomic characterization benefits the identification of acute lung injury in patients with type A acute aortic dissection.

ABSTRACT: Introduction: Acute aortic dissection (AAD) often leads to the development of acute lung injury (ALI). However, the early detection and diagnosis of AAD in patients with ALI pose significant challenges. The objective of this study is to investigate distinct metabolic alterations in the plasma samples of AAD patients with ALI, AAD patients without ALI, and healthy individuals. Method: Between September 2019 and September 2022, we retrospectively collected data from 228 AAD patients who were diagnosed with ALI through post-surgery chest X-ray and PaO₂/FiO₂ assessments. Univariate analysis was employed to identify pre-surgery risk factors for ALI. Additionally, we conducted high-throughput target metabolic analysis on 90 plasma samples, comprising 30 sample

SUBMITTER: Fan L 

PROVIDER: S-EPMC10434778 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature