A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment.

ABSTRACT: Antimicrobial resistant bacterial infections represent one of the most serious contemporary global healthcare crises. Acquisition and spread of resistant infections can occur through community, hospitals, food, water or endogenous bacteria. Global efforts to reduce resistance have typically focussed on antibiotic use, hygiene and sanitation and drug discovery. However, resistance in endogenous infections, e.g. many urinary tract infections, can result from life-long acquisition and persistence of resistance genes in commensal microbial flora of individual patients, which is not normally considered. Here, using individual based Monte Carlo models calibrated using antibiotic use data and human gut resistomes, we show that the long-term increase in resistance in human gut microbiomes can be s

SUBMITTER: Todman H 

PROVIDER: S-EPMC10434901 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature