Ovulation induction is associated with altered growth but with preservation of normal metabolic function in murine offspring.

ABSTRACT:

Objective

To study the effects of ovulation induction on mouse postnatal health, with a focus on growth pattern and glucose tolerance. To study the effect of ovulation induction on DNA methylation, we took advantage of the agouti viable yellow (A^vy) mouse.

Design

Animal study.

Setting

University Setting.

Animals

Agouti viable yellow (A^vy) mice on a C57BL/6 background.

Intervention(s)

A^vy female mice were either allowed to mate spontaneously (control group, C) or after superovulation with 5 IU of PMSG and hCG (ovulation induction group, OI).

Main outcome measure(s)

Birth parameters and postnatal growth of the offspring were followed up to 29 weeks of age. Body composition analysis was performed by EchoMRI; fasting i

SUBMITTER: Harner R 

PROVIDER: S-EPMC10434990 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature