Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.

ABSTRACT:

Background and objectives

Observational studies suggested a bidirectional relationship between Alzheimer disease (AD) and epilepsies. However, it remains debated whether and in which direction a causal association exists. This study aims to explore the relationship between genetic predisposition to AD, CSF biomarkers of AD (β-amyloid [Aβ] 42 and phosphorylated tau [pTau]), and epilepsies with 2-sample, bidirectional Mendelian randomization (MR) method.

Methods

Genetic instruments were obtained from large-scale genome-wide meta-analysis of AD (N_case/proxy = 111,326, N_control = 677,663), CSF biomarkers of AD (Aβ42 and pTau, N = 13,116), and epilepsy (N_case = 15,212, N_control = 29,677) of European ancestry. Epilepsy phenotypes include

SUBMITTER: Fang Y 

PROVIDER: S-EPMC10435057 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature