Environmental carcinogens disproportionally mutate genes implicated in neurodevelopmental disorders.

ABSTRACT:

Introduction

De novo mutations contribute to a large proportion of sporadic psychiatric and developmental disorders, yet the potential role of environmental carcinogens as drivers of causal de novo mutations in neurodevelopmental disorders is poorly studied.

Methods

To explore environmental mutation vulnerability of disease-associated gene sets, we analyzed publicly available whole genome sequencing datasets of mutations in human induced pluripotent stem cell clonal lines exposed to 12 classes of environmental carcinogens, and human lung cancers from individuals living in highly polluted regions. We compared observed rates of exposure-induced mutations in disease-related gene sets with the expected rates of mutations based on control genes randomly sampled from

SUBMITTER: Baker BH 

PROVIDER: S-EPMC10435087 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature