Chronic unpredictable mild stress alters odor hedonics and adult olfactory neurogenesis in mice.

ABSTRACT: Experiencing chronic stress significantly increases the risk for depression. Depression is a complex disorder with varied symptoms across patients. However, feeling of sadness and decreased motivation, and diminished feeling of pleasure (anhedonia) appear to be core to most depressive pathology. Odorants are potent signals that serve a critical role in social interactions, avoiding danger, and consummatory behaviors. Diminished quality of olfactory function is associated with negative effects on quality of life leading to and aggravating the symptoms of depression. Odor hedonic value (I like or I dislike this smell) is a dominant feature of olfaction and guides approach or avoidance behavior of the odor source. The neural representation of the hedonic value of odorants is carried by the gr

SUBMITTER: Athanassi A 

PROVIDER: S-EPMC10435088 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature