Pan-cancer analysis of Kruppel-like factor 3 and its carcinogenesis in pancreatic cancer.

ABSTRACT:

Background

Krüppel-like factor 3 (KLF3) is a key transcriptional repressor, which is involved in various biological functions such as lipogenesis, erythropoiesis, and B cell development, and has become one of the current research hotspots. However, the role of KLF3 in the pan-cancer and tumor microenvironment remains unclear.

Methods

TCGA and GTEx databases were used to evaluate the expression difference of KLF3 in pan-cancer and normal tissues. The cBioPortal database and the GSCALite platform analyzed the genetic variation and methylation modification of KLF3. The prognostic role of KLF3 in pan-cancer was identified using Cox regression and Kaplan-Meier analysis. Correlation analysis was used to explore the relationship between KLF3

SUBMITTER: Zhu J 

PROVIDER: S-EPMC10435259 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature