Study of the human hippocampal formation: a method for histological and magnetic resonance correlation in perinatal cases.

ABSTRACT: Little information is available on the magnetic resonance imaging (MRI) determination of the hippocampal formation (HF) during the perinatal period. However, this exploration is increasingly used, which requires defining visible HF landmarks on MRI images, validated through histological analysis. This study aims to provide a protocol to identify HF landmarks on MRI images, followed by histological validation through serial sections of the temporal lobe of the samples examined, to assess the longitudinal extent of the hippocampus during the perinatal period. We examined ex vivo MRI images from nine infant control brain samples. Histological validation of the hippocampal formation MRI images was obtained through serial sectioning and examination of Nissl-stained sections at 250 μm intervals

SUBMITTER: Gonzalez Fuentes J 

PROVIDER: S-EPMC10435394 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature