Excessive vincristine exposure in a child being treated for acute lymphoblastic leukaemia with underlying Dubin-Johnson syndrome: a case report.

ABSTRACT:

Background

Dubin-Johnson syndrome is a rare benign autosomal recessive condition that causes an isolated increase of conjugated bilirubin in the serum. Impaired biliary excretion is due to mutation in the multiple drug-resistance protein 2 gene (MRP2).

Case presentation

We describe the case of a 4-year-old girl being treated for acute lymphoblastic leukaemia who had a history of conjugated hyperbilirubinaemia and persistently elevated bilirubin levels on initiation of chemotherapy. During treatment for leukaemia, she was diagnosed with Dubin-Johnson syndrome for the underlying condition. Following administration of vincristine at the recommended dose of 1.5 mg/m², an abnormally high vincristine exposure was observed (AUC > 200 µg/L*h), approximately 3 times higher

SUBMITTER: Barnett S 

PROVIDER: S-EPMC10435398 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature