MIB2 promotes the progression of non-small cell lung cancer by regulating cell cycle control pathways.

ABSTRACT:

Background

Although numerous measures have been used to improve the outcome of lung cancer patients, lung cancer, as the second most common diagnosed cancer, is still the main cause of cancer death. It becomes increasingly urgent for us to deeply deplore the molecular mechanism of lung cancer and to discover the potential therapeutic targets. In our study, we are dedicated to discovering the role of MIB2 in lung cancer development.

Methods

The public databases were used to compare the expression level of MIB2 in cancer and non-cancer tissue. We analyzed the expression of MIB2 in lung cancer samples by performing Rt-PCR and western blot. We carried out CCK8 and clone assays to study the influence of MIB2 in lung cancer proliferation. The transwell assays and wound healing ass

SUBMITTER: Kong Y 

PROVIDER: S-EPMC10435422 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature