T-cell phenotype including CD57⁺ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma.

ABSTRACT: T-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL). However, the phenotype of T-cells may vary, and the prevalence of certain T-cell subsets may influence tumor biology and patient survival. We therefore analyzed a cohort of 82 FL patients using CyTOF to determine whether specific T-cell phenotypes were associated with distinct tumor microenvironments and patient outcome. We identified four immune subgroups with differing T-cell phenotypes and the prevalence of certain T-cell subsets was associated with patient survival. Patients with increased T cells with early differentiation stage tended to have a significantly better survival than patients with increased T-cells of late differentiation stage. Specifically, CD57⁺ T_FH cells, with

SUBMITTER: Yang ZZ 

PROVIDER: S-EPMC10435479 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature