Mechanisms of peripheral sensitization in endometriosis patients with peritoneal lesions and acyclical pain.

ABSTRACT:

Purpose

Endometriosis (EM) is one of the most frequent differential diagnoses concerning chronic pelvic pain. Women under hormonal therapy (HT) often benefit from it but sometimes suffer a setback and develop acyclical pelvic pain. Due to the assumption that mechanisms of neurogenic inflammation are involved in the generation of chronic pelvic pain, we aimed to investigate the expression of sensory nerve markers in EM-associated nerve fibers of patients with/without HT.

Methods

Laparoscopically excised peritoneal samples from 45 EM and 10 control women were immunohistochemically stained for: PGP9.5, Substance P (SP), NK1R, NGFp75, TRPV-1, and TrkA. Demographics and severity of pain were documented.

Results

EM patients showed a higher nerve fiber density (PGP9.5 and SP

SUBMITTER: Velho RV 

PROVIDER: S-EPMC10435658 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature