Structural and functional changes of the cerebellum in temporal lobe epilepsy.

ABSTRACT:

Aims

This study aimed to comprehensively explore the cerebellar structural and functional changes in temporal lobe epilepsy (TLE) and its association with clinical information.

Methods

The SUIT toolbox was utilized to perform cerebellar volume and diffusion analysis. In addition, we extracted the average diffusion values of cerebellar peduncle tracts to investigate microstructure alterations. Seed-based whole-brain analysis was used to investigate cerebellar-cerebral functional connectivity (FC). Subgroup analyses were performed to identify the cerebellar participation in TLE with/without hippocampal sclerosis (HS)/focal-to-bilateral tonic-clonic seizure (FBTCS) and TLE with different lateralization.

Results

TLE showed widespread gray matter atrophy in bilateral crusI

SUBMITTER: Wang G 

PROVIDER: S-EPMC10435757 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature