Metabolic features of orbital adipose tissue in patients with thyroid eye disease.

ABSTRACT:

Background

Thyroid eye disease (TED) is the most frequent orbital disease in adults and is characterized by the accumulation of orbital adipose tissue (OAT). It can lead to eyelid retraction or even vision loss. Orbital decompression surgery serves as the primary treatment for inactive TED by removing the excess OAT. However, there is a lack of alternative treatments to surgery due to the unclear understanding of the pathogenesis, particularly the metabolic features. Accordingly, our study was implemented to explore the content and features of metabolites of OATs from TED patients.

Method

The OATs used in the current study were obtained from the orbital decompression surgery of seven patients with inactive TED. We also collected control OATs from eye surgical samples of five

SUBMITTER: Du R 

PROVIDER: S-EPMC10435847 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature